National Registry of Certified Medical Examiners (NRCME) DOT Practice Exam

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Severe elevations in HgbA1C can result in which of the following complications?

  1. Neuropathy

  2. Cirrhosis

  3. Retinal detachment

  4. Heart failure

The correct answer is: Neuropathy

Severe elevations in hemoglobin A1C (HgbA1C) are indicative of chronic hyperglycemia and are closely associated with various complications of diabetes, particularly neuropathy. Elevated HgbA1C levels reflect poor long-term blood glucose control, which can damage nerve fibers and lead to diabetic neuropathy. This condition is characterized by symptoms such as pain, tingling, and loss of sensation, primarily in the extremities. While other complications related to diabetes, such as cardiovascular issues or visual problems, can also arise due to high blood sugar levels, neuropathy is one of the most commonly recognized conditions stemming directly from prolonged elevated blood glucose levels. By focusing on the direct connection between high HgbA1C and nerve damage, it becomes clear why neuropathy is the correct choice in this context.