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The correct answer is Coumadin (Warfarin) because this medication is an anticoagulant used to prevent blood clots. For individuals taking Warfarin, monitoring of INR (International Normalized Ratio) levels is essential to ensure that the blood's clotting ability remains within a safe range. An INR that is too low may indicate an increased risk of clotting, while a high INR may lead to a risk of bleeding, both of which could compromise the safety of an individual operating a vehicle.

On the other hand, medications like aspirin and ibuprofen are nonsteroidal anti-inflammatory drugs (NSAIDs) that are not monitored with INR levels. Although they can affect platelet function and blood clotting, they do not require the same level of monitoring as Warfarin, which is specifically tailored to manage the delicate balance of coagulation needed for patients at risk of thrombosis. Metformin, commonly used for managing type 2 diabetes, also does not require INR monitoring, as its mechanism of action does not involve anticoagulation. Thus, Coumadin (Warfarin) stands out as the drug that necessitates INR monitoring for safe driver certification.